منابع مشابه
Diabetes in HFE Hemochromatosis
Diabetes in whites of European descent with hemochromatosis was first attributed to pancreatic siderosis. Later observations revealed that the pathogenesis of diabetes in HFE hemochromatosis is multifactorial and its clinical manifestations are heterogeneous. Increased type 2 diabetes risk in HFE hemochromatosis is associated with one or more factors, including abnormal iron homeostasis and iro...
متن کاملSecondary hemochromatosis. I. Transfusion (exogenous) hemochromatosis.
(" bronszed diabetes ") is a condition of unknown etiology in which the body iron stores are vastly inscreased ansd in which there is portal cirrhosis of the liver. Diabetes, pigmenstation of the skins, and pan-creatic fibrosis are frequently, though not invariably, present. Numerous blood transsfusionss ins certain patienits have resulted ins the productions of a condition clinically somewhat ...
متن کاملHemochromatosis and ovarian cancer.
Evaluation of: Gannon PO, Medelci S, Le Page C et al. Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis. Int. J. Cancer 128(10), 2326-2334 (2011). The frequency of two mutations (C282Y and D62H) of the hemochromatosis gene were investigated in women with ovarian cancer. A single allele mutation of the C282Y but not the H63D gene product was detected ...
متن کاملHemochromatosis and Iron Metabolism
Hereditary hemochromatosis Hereditary hemochromatosis (HH) is characterized by abnormal iron absorption from the diet resulting in progressive iron overload, causing tissue damage of several organs, particularly the liver (1). Historically HH has been regarded as an extremely rare inborn error of metabolism causing "bronze diabetes", liver cirrhosis and hepatocellular carcinoma due to heavy iro...
متن کاملExperimental Hemochromatosis
In pernicious anemia and hemochromatosis an iron-containing pigment, hemosiderin, ordinarily derived from hemoglobin, is deposited in organs free from such pigment in most conditions that involve blood destruction. When sudden hemolysis takes place in a previously healthy human being, as after cutaneous burns or the action of a "blood poison," hemosiderin granules appear in the spleen, the red ...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 1994
ISSN: 0025-6196
DOI: 10.1016/s0025-6196(12)61803-5